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Pharmacological action

Cymbalta is an antidepressant of the selective serotonin and norepinephrine reuptake inhibitors group, prescribed to the patients with the general anxiety disorder, major depressive disorder, fibromyalgia (chronic pain disorder), chronic musculoskeletal pain and diabetic neuropathy.

Pharmacokinetics: Cymbalta is well absorbed after the peroral administration of the drug dose. The maximum concentration of the drug in blood plasma is reached in 6 hours after the Cymbalta dose intake. The intake of the drug together with the food does not affect the Cmax of Cymbalta, but in this case the maximum concentration of the drug in the blood plasma is reached in 6-10 hours after the dose intake. Cymbalta has 90% binding to human plasma proteins.
The Cymbalta elimination half-life in the human body is from 8 to 17 hours. The drug is eliminated through hepatic metabolism. 1% (or less) of the drug is eliminated unchanged with the urine, and about 70% is eliminated with the urine in the form of Cymbalta metabolites. 20% of the drug is excreted with the feces. Buy Aciphex No Prescription

Indications for use: Cymbalta is as a rule prescribed for the major depressive disorder (MDD), often accompanied with such symptoms as mood swings, loss of interest for usual daily activities, changes in body weight and loss of appetite, sleep disorders, such as insomnia or hypersomnia, psychomotor agitation, psychomotor retardation, impaired concentration, the decrease in mental activity and inhibition of thinking, fatigue, suicide attempt or inclinations for suicide. It also turns to be very effective for the generalized anxiety disorder treatment, diabetic peripheral neuropathic pain treatment and fibromyalgia. Cymbalta therapy can also be prescribed for the treatment of chronic musculoskeletal pain, cause by the osteoarthritis in patients. Buy Norvasc no prescription

Side effects: As any other drug Cymbalta has the range of side effects. Among the less severe ones there are dry mouth, drowsiness, fatigue, mild nausea, the loss of appetite or constipation. But it is able to cause more severe side effects, such as mood swings, anxiety, panic attacks, sleep disorders, as well as impulsivity, irritability, agitation, aggression, mental or physical hyperactivity and depression. While following Cymbalta therapy pain in your upper itching, stomach, loss of appetite, jaundice or dark urine can be observed. The Cymbalta intake can also provoke hallucinations, fever, fast heart rate, myotonia, sweating, tremors, difficult urination, loss of concentration and coordination, memory problems, headaches or skin reactions (sore throat, eyes burning, red or purple skin rash). In case you experience any of the side effects above listed or other while you follow the Cymbalta treatment, you should immediately consult your doctor. propecia no prescription

Contraindications: Cymbalta is not recommended for the intake to the patients, who recently followed the Mellaril treatment or monoamine oxidase inhibitor (MAOI). It is also not recommended for the patients with kidney or liver failures, uncontrolled narrow-angle glaucoma, diabetes and bipolar disorder. Taken together with the aspirin, NSAID pain relievers, or blood thinners, Cymbalta can cause abnormal bleedings. This drug cannot be prescribed to the pregnant women or nursing mothers. Nexium No Prescription

Interaction with other drugs: Cymbalta is not recommended for the intake to the patients, who take blood thinners (like warfarin), cimetidine, diuretics, fluvoxamine, linezolid, lithium, tramadol, tryptophan, antibiotics (such as ciprofloxacin), almotriptan, frovatriptan, sumatriptan, naratriptan, rizatriptan, zolmitriptan, or antidepressants, such as desipramine, fluoxetine, paroxetine and some others. Clomid Without Prescription

Precautionary measures: In patients, whose professional or other daily activities need focus and fast reactions Cymbalta should be administered with great care. In case of following Cymbalta treatment it is better to avoid driving a car, hazardous machinery operating, drinking alcohol or taking any other drugs together with Cymbalta without consulting your doctor. This drug is not recommended for the intake in patients aged less than 18 years old. Arimidex without Prescription As the effective and powerful antidepressant Cymbalta is able to provoke the inclinations for suicide, especially in young patients aged less than 24 years old. In case you start having suicidal thoughts while following Cymbalta treatment, you should consult your doctor and report him about these symptoms.
Cymbalta is the prescription drug. Never use Cymbalta before you consult your doctor first.

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